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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLK1
All Species:
41.82
Human Site:
S390
Identified Species:
57.5
UniProt:
P53350
Number Species:
16
Phosphosite Substitution
Charge Score:
0.06
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P53350
NP_005021.2
603
68255
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Chimpanzee
Pan troglodytes
XP_001163623
603
68223
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Rhesus Macaque
Macaca mulatta
XP_001092070
603
68240
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Dog
Lupus familis
XP_547091
832
93293
S618
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q07832
603
68282
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Rat
Rattus norvegicus
Q62673
603
68295
S390
S
V
N
A
S
K
P
S
E
R
G
L
V
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505317
482
55166
E277
R
R
L
V
K
Q
E
E
A
E
D
P
A
C
N
Chicken
Gallus gallus
NP_001025810
595
66904
S381
A
V
N
S
A
K
P
S
E
R
T
A
V
R
Q
Frog
Xenopus laevis
P70032
598
68193
S384
C
L
N
A
V
K
P
S
E
R
A
L
I
R
Q
Zebra Danio
Brachydanio rerio
NP_001003890
595
67743
S381
V
V
N
A
A
K
P
S
D
R
D
F
I
R
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P52304
576
66955
S353
R
H
S
E
D
Y
R
S
D
I
E
S
L
Y
Q
Honey Bee
Apis mellifera
XP_396707
575
66141
S369
A
V
L
K
A
K
P
S
R
E
T
T
S
S
A
Nematode Worm
Caenorhab. elegans
P34331
649
73615
P391
V
L
L
E
Q
R
I
P
G
L
E
E
E
E
A
Sea Urchin
Strong. purpuratus
XP_784826
587
66895
S371
S
V
V
A
A
K
P
S
E
K
A
D
I
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P0C8M8
626
70215
S370
T
L
V
T
S
P
H
S
A
T
T
Q
A
H
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9STV4
445
50410
N240
L
G
A
K
S
L
I
N
R
I
L
D
P
N
P
Baker's Yeast
Sacchar. cerevisiae
P32562
705
81013
A451
R
E
A
R
I
R
R
A
Q
Q
A
V
L
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.8
69.5
N.A.
95
94.1
N.A.
69.3
80
79.7
74.3
N.A.
50.7
51.4
49.9
59.3
Protein Similarity:
100
99.8
99.8
71
N.A.
97.6
96.8
N.A.
74.7
89.8
90.5
87.5
N.A.
69.4
69.9
66.2
76.4
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
66.6
66.6
60
N.A.
13.3
26.6
0
53.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
6.6
86.6
80
80
N.A.
33.3
40
13.3
73.3
Percent
Protein Identity:
N.A.
31.7
N.A.
26
33.9
N.A.
Protein Similarity:
N.A.
50.1
N.A.
40.4
51.6
N.A.
P-Site Identity:
N.A.
13.3
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
12
53
24
0
0
6
12
0
18
6
12
0
12
% A
% Cys:
6
0
0
0
0
0
0
0
0
0
0
0
0
6
0
% C
% Asp:
0
0
0
0
6
0
0
0
12
0
12
12
0
0
0
% D
% Glu:
0
6
0
12
0
0
6
6
53
12
12
6
6
6
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
6
0
0
0
% F
% Gly:
0
6
0
0
0
0
0
0
6
0
36
0
0
0
0
% G
% His:
0
6
0
0
0
0
6
0
0
0
0
0
0
6
0
% H
% Ile:
0
0
0
0
6
0
12
0
0
12
0
0
18
0
0
% I
% Lys:
0
0
0
12
6
65
0
0
0
6
0
0
0
0
6
% K
% Leu:
6
18
18
0
0
6
0
0
0
6
6
42
12
0
6
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
53
0
0
0
0
6
0
0
0
0
0
6
6
% N
% Pro:
0
0
0
0
0
6
65
6
0
0
0
6
6
0
6
% P
% Gln:
0
0
0
0
6
6
0
0
6
6
0
6
0
0
59
% Q
% Arg:
18
6
0
6
0
12
12
0
12
53
0
0
0
65
0
% R
% Ser:
42
0
6
6
48
0
0
77
0
0
0
6
6
6
0
% S
% Thr:
6
0
0
6
0
0
0
0
0
6
18
6
0
0
6
% T
% Val:
12
59
12
6
6
0
0
0
0
0
0
6
42
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
6
0
0
0
0
0
0
0
6
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _